发明申请
WO9828268A3 CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA -AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
审中-公开
基本信息:
- 专利标题： CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA -AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
- 专利标题（中）：环己基，LACTAM，LACTONE和相关化合物，包含它们的药物组合物，以及用于抑制β-氨基乙酸酯释放的方法和/或其通过使用这些化合物的合成
- 申请号：PCT/US9722986 申请日：1997-12-22
- 公开(公告)号：WO9828268A3 公开(公告)日：1998-10-08
- 发明人： WU JING , TUNG JAY S , THORSETT EUGENE D , PLEISS MICHAEL A , NISSEN JEFFREY S , NEITZ JEFFREY , LATIMER LEE H , JOHN VARGHESE , FREEDMAN STEPHEN , BRITTON THOMAS C , AUDIA JAMES E , REEL JON K , MABRY THOMAS E , DRESSMAN BRUCE A , CWI CYNTHIA L , DROSTE JAMES J , HENRY STEVEN S , MCDANIEL STACEY L , SCOTT WILLIAM LEONARD , STUCKY RUSSELL D , PORTER WARREN J
- 申请人： ATHENA NEUROSCIENCES INC , LILLY CO ELI , WU JING , TUNG JAY S , THORSETT EUGENE D , PLEISS MICHAEL A , NISSEN JEFFREY S , NEITZ JEFFREY , LATIMER LEE H , JOHN VARGHESE , FREEDMAN STEPHEN , BRITTON THOMAS C , AUDIA JAMES E , REEL JON K , MABRY THOMAS E , DRESSMAN BRUCE A , CWI CYNTHIA L , DROSTE JAMES J , HENRY STEVEN S , MCDANIEL STACEY L , SCOTT WILLIAM LEONARD , STUCKY RUSSELL D , PORTER WARREN J
- 专利权人： ATHENA NEUROSCIENCES INC,LILLY CO ELI,WU JING,TUNG JAY S,THORSETT EUGENE D,PLEISS MICHAEL A,NISSEN JEFFREY S,NEITZ JEFFREY,LATIMER LEE H,JOHN VARGHESE,FREEDMAN STEPHEN,BRITTON THOMAS C,AUDIA JAMES E,REEL JON K,MABRY THOMAS E,DRESSMAN BRUCE A,CWI CYNTHIA L,DROSTE JAMES J,HENRY STEVEN S,MCDANIEL STACEY L,SCOTT WILLIAM LEONARD,STUCKY RUSSELL D,PORTER WARREN J
- 当前专利权人： ATHENA NEUROSCIENCES INC,LILLY CO ELI,WU JING,TUNG JAY S,THORSETT EUGENE D,PLEISS MICHAEL A,NISSEN JEFFREY S,NEITZ JEFFREY,LATIMER LEE H,JOHN VARGHESE,FREEDMAN STEPHEN,BRITTON THOMAS C,AUDIA JAMES E,REEL JON K,MABRY THOMAS E,DRESSMAN BRUCE A,CWI CYNTHIA L,DROSTE JAMES J,HENRY STEVEN S,MCDANIEL STACEY L,SCOTT WILLIAM LEONARD,STUCKY RUSSELL D,PORTER WARREN J
- 优先权： US78002596 1996-12-23
- 主分类号： C07D243/16
- IPC分类号： C07D243/16 ; A61K31/55 ; A61K31/551 ; A61K31/5513 ; A61K31/5517 ; A61K38/00 ; A61P25/28 ; A61P43/00 ; C07C20060101 ; C07C237/22 ; C07D207/26 ; C07D207/273 ; C07D211/76 ; C07D223/10 ; C07D223/16 ; C07D223/18 ; C07D243/12 ; C07D243/24 ; C07D243/38 ; C07D267/14 ; C07D281/10 ; C07D307/33 ; C07D309/30 ; C07D401/04 ; C07D401/14 ; C07D409/12 ; C07D409/14 ; C07D487/04 ; C07K5/087 ; C07K5/113 ; C07K14/18 ; C07D
摘要：
Disclosed are compounds for Formula (I) wherein the substituents are as defined in the claims which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D243/00 | 杂环化合物，含七元环，有两个氮原子作为仅有的杂环原子 |
| --------C07D243/06 | .氮原子在位置1和4 |
| ----------C07D243/10 | ..与碳环或碳环系稠合 |
| ------------C07D243/14 | ...1,4-苯并二氮杂；氢化1,4-苯并二氮杂 |
| --------------C07D243/16 | ....在位置5被芳基取代 |