基本信息:
- 专利标题： THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS
- 专利标题（中）：作为蛋白激酶C抑制剂的噻唑衍生物
- 申请号：PCT/JP1997002609 申请日：1997-07-29
- 公开(公告)号：WO1998004536A1 公开(公告)日：1998-02-05
- 发明人： OTSUKA PHARMACEUTICAL COMPANY, LIMITED
- 申请人： OTSUKA PHARMACEUTICAL COMPANY, LIMITED , MORI, Toyoki , TOMINAGA, Michiaki , TABUSA, Fujio , NAGAMI, Kazuyoshi , ABE, Kaoru , NAKAYA, Kenji , TAKEMURA, Isao , SHINOHARA, Tomoichi , TANADA, Yoshihisa , YAMAUCHI, Takahito
- 专利权人： OTSUKA PHARMACEUTICAL COMPANY, LIMITED,MORI, Toyoki,TOMINAGA, Michiaki,TABUSA, Fujio,NAGAMI, Kazuyoshi,ABE, Kaoru,NAKAYA, Kenji,TAKEMURA, Isao,SHINOHARA, Tomoichi,TANADA, Yoshihisa,YAMAUCHI, Takahito
- 当前专利权人： OTSUKA PHARMACEUTICAL COMPANY, LIMITED,MORI, Toyoki,TOMINAGA, Michiaki,TABUSA, Fujio,NAGAMI, Kazuyoshi,ABE, Kaoru,NAKAYA, Kenji,TAKEMURA, Isao,SHINOHARA, Tomoichi,TANADA, Yoshihisa,YAMAUCHI, Takahito
- 优先权： JP8/200898 19960731
- 主分类号： C07D277/82
- IPC分类号： C07D277/82
摘要：
A thiazole compound of formula (I), wherein T is lower alkylene; u is 0 or 1; R and R are the same or different and are each H, or lower alkyl, etc.; R is (1) or (2); R is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity or protein kinase C(PKC, Ca /phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.
摘要（中）：
式（I）的噻唑化合物，其中T为低级亚烷基; 你是0或1; R 1和R 2相同或不同，各自为H或低级烷基等; R 3为（1）或（2）; R 4是H或低级烷酰氧基 - 低级烷基，其表现出抑制活性或蛋白激酶C（PKC，Ca 2+ /磷脂依赖性丝氨酸/苏氨酸蛋白磷酸酶），可用作蛋白激酶C抑制剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D277/00 | 杂环化合物，含有1,3-噻唑或氢化1,3-噻唑环 |
| --------C07D277/02 | .不和其他环稠合 |
| ----------C07D277/62 | ..苯并噻唑 |
| ------------C07D277/64 | ...仅有烃基和取代烃基连接在位置2上 |
| --------------C07D277/82 | ....氮原子 |