基本信息:
- 专利标题： DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
- 专利标题（中）：二苯醚作为钾通道调节剂
- 申请号：PCT/US1997014352 申请日：1997-07-30
- 公开(公告)号：WO1998004135A1 公开(公告)日：1998-02-05
- 发明人： BRISTOL-MYERS SQUIBB COMPANY , ROMINE, Jeffrey, L. , MARTIN, Scott, W. , HEWAWASAM, Piyasena , MEANWELL, Nicholas, A. , GRIBKOFF, Valentin, K. , STARRETT, John, E., Jr.
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 优先权： US60/022,983 19960731
- 主分类号： A01N43/653
- IPC分类号： A01N43/653
摘要：
Novel compounds of formula (1) are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels, wherein "Het" is one of a select group of heterocyclic moieties; Z is independently for each occurrence selected from O or S; R , R and R each are independently selected from hydrogen, halogen, OH, CF3, NO2, or (a); provided R is not hydrogen; and when R and R are hydrogen, R may be a heterocyclic moiety selected from the group consisting of imidazol-1-yl, morpholinomethyl, N-methylimidazol-2-yl, and pyridin-2-yl; R and R each are independently selected form hydrogen, halogen, CF3, NO2 or imidazol-1-yl; m, n and p each are independently selected from an integer of 0 or 1; and R and R each are independently hydrogen; C1-4 alkyl; or R and R , taken together with the nitrogen atom to which they are attached, is a heterocyclic moiety selected from the group consisting of N-methylpiperazine, morpholine, thiomorpholine, N-benzylpiperazine and imidazolinone.
摘要（中）：
式（1）的新型化合物可用于治疗对大电导钙激活钾通道的开放物起反应的病症，其中“Het”是选择性杂环部分组之一; Z独立地选自O或S; R a，R b和R c各自独立地选自氢，卤素，OH，CF 3，NO 2或（a）; 条件是R c不是氢; 当R a和R b为氢时，R c可以是选自咪唑-1-基，吗啉代甲基，N-甲基咪唑-2-基和吡啶-2-基的杂环部分， 基; R d和R e各自独立地选自氢，卤素，CF 3，NO 2或咪唑-1-基; m，n和p各自独立地选自0或1的整数; 和R f和R g各自独立地为氢; C 1-4烷基; 或R f和R g与它们所连接的氮原子一起是选自N-甲基哌嗪，吗啉，硫代吗啉，N-苄基哌嗪和咪唑啉酮的杂环部分。