基本信息:
- 专利标题: N-ACYL SULFAMIC ACID ESTERS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS
- 专利标题(中):N-乙酰基硫酸酯有机物作为高效液相色谱
- 申请号:PCT/US1997006725 申请日:1997-04-21
- 公开(公告)号:WO1997044314A1 公开(公告)日:1997-11-27
- 发明人: WARNER-LAMBERT COMPANY
- 申请人: WARNER-LAMBERT COMPANY , LEE, Helen, Tsenwhei , PICARD, Joseph, Armand , ROARK, William, Howard , ROTH, Bruce, David , SLISKOVIC, Drago, Robert
- 专利权人: WARNER-LAMBERT COMPANY,LEE, Helen, Tsenwhei,PICARD, Joseph, Armand,ROARK, William, Howard,ROTH, Bruce, David,SLISKOVIC, Drago, Robert
- 当前专利权人: WARNER-LAMBERT COMPANY,LEE, Helen, Tsenwhei,PICARD, Joseph, Armand,ROARK, William, Howard,ROTH, Bruce, David,SLISKOVIC, Drago, Robert
- 优先权: US60/017,882 19960517
- 主分类号: C07C307/02
- IPC分类号: C07C307/02
摘要:
The instant invention is new compounds of formula (I), wherein R is -CN, -(CH2)0-1-NR R , -O-(CH2)1-10-Z wherein Z is -NR R , OR , or CO2R , -OC(=O)R , -SR , -SCN, -S(CH2)1-10Z, -S(O)1-2R wherein R is hydroxy, alkoxy, alkyl, (CH2)1-10Z or NR R , -C(=O)XR , -CH2-R wherein R is (CH2)0-5-Y-(CH2)0-5Z, or alkyl with from 1-3 double bonds, which alkyl is optionally substituted by one or more selected from -CN, NO2, halogen, OR , NR R , and CO2R ; their use as cerebrovascular agents in diseases such as stroke, peripheral vascular disease, restenosis, and as agents for regulating plasma cholesterol concentrations, for treating hypercholesterolemia and atherosclerosis, and for lowering the serum or plasma level of Lp(a). A pharmaceutical composition is also claimed.
摘要(中):
本发明是新的式(I)化合物,其中R 6是-CN, - (CH 2)0-1 -NR 7 R 8,-O-(CH 2)1-10 -Z,其中 Z是-NR 9 R 10,OR 1或CO 2 R 1,-OC(= O)R 11,-SR 11,-SCN,-S(CH 2) 10Z,-S(O)1-2R 12其中R 12是羟基,烷氧基,烷基,(CH 2)1-10Z或NR 7 R 8,-C(= O)X R 11 其中R 13为(CH 2)0-5-Y-(CH 2)0-5Z,或具有1-3个双键的烷基,该烷基任选被一个或多个 选自-CN,NO 2,卤素,OR 1,NR 9 R 10和CO 2 R 1; 它们用作中风,外周血管疾病,再狭窄等疾病中的脑血管因子,以及用于调节血浆胆固醇浓度的药剂,用于治疗高胆固醇血症和动脉粥样硬化,以及降低Lp(a)的血清或血浆水平。 还要求药物组合物。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C307/00 | 硫酸酰胺,即含有被不属于硝基或亚硝基的氮原子取代的硫酸酯基的氧原子的化合物 |
--------C07C307/02 | .硫酸或其酯的单酰胺,例如,氨基磺酸 |