基本信息:
- 专利标题： PYRIDAZINOQUINOLINE COMPOUNDS
- 专利标题（中）：吡啶并喹啉化合物
- 申请号：PCT/GB1995002613 申请日：1995-11-08
- 公开(公告)号：WO1996015127A1 公开(公告)日：1996-05-23
- 发明人： ZENECA LIMITED
- 申请人： ZENECA LIMITED , BARE, Thomas, Michael , CHAPDELAINE, Marc, Jerome , DAVENPORT, Timothy, Wayne , EMPFIELD, James, Roy , GARCIA-DAVENPORT, Laura, Enid , JACKSON, Paul, Francis , McKINNEY, Jeffrey, Alan , McLAREN, Charles, David , SPARKS, Richard, Bruce
- 专利权人： ZENECA LIMITED,BARE, Thomas, Michael,CHAPDELAINE, Marc, Jerome,DAVENPORT, Timothy, Wayne,EMPFIELD, James, Roy,GARCIA-DAVENPORT, Laura, Enid,JACKSON, Paul, Francis,McKINNEY, Jeffrey, Alan,McLAREN, Charles, David,SPARKS, Richard, Bruce
- 当前专利权人： ZENECA LIMITED,BARE, Thomas, Michael,CHAPDELAINE, Marc, Jerome,DAVENPORT, Timothy, Wayne,EMPFIELD, James, Roy,GARCIA-DAVENPORT, Laura, Enid,JACKSON, Paul, Francis,McKINNEY, Jeffrey, Alan,McLAREN, Charles, David,SPARKS, Richard, Bruce
- 优先权： GB9422894.7 19941112
- 主分类号： C07D471/04
- IPC分类号： C07D471/04
摘要：
The invention relates to pyridazinoquinoline coumpounds of formulae A and A', wherein: ring A is chosen from an ortho fused aromatic or heteroaromatic five- or six-membered ring; R is selected from the group consisting of halo, (1-4C)alkyl, NO2, CN, (C1-3)perfluoroalkyl, OH, OCF3, (2-4C)alkenyl, (2-4C)alkynyl, O(1-4C)alkyl, NR'R", SO2NR'R", or SOmR'; R is selected from H, (1-6C)alkyl, or -(CH2)nL; R is selected from H or -(CH2)nL; L is a variety of substituents including phenyl, heterocyclic groups and heteroaryl; n is 0-6; m is 0-2, R is selected from H, (1-6C)alkyl or (1-6C)alkylaryl; R is selected from H or -(CO)R wherein R is selected from a variety of substituents including hydrogen, (1-12C)alkyl, pyridyl, phenyl, pyridyl (1-12C)alkyl and phenyl (1-4C)alkyl; and R' and R" are selected from H, (1-4C)alkyl, (3-6C)cycloalkyl, phenyl (0-4)alkyl-, heterocycle (0-4C)alkyl- or heteroaryl (0-4C)alkyl- to pharmaceutical compositions containing them and to methods for the treatment of neurological disorders utilizing them.
摘要（中）：
本发明涉及式A和A'的哒嗪喹啉基团，其中：环A选自邻近稠合芳族或杂芳族五元或六元环; R 4选自卤素，（1-4C）烷基，NO 2，CN，（C 1-3）全氟烷基，OH，OCF 3，（2-4C）烯基，（2-4C）炔基，O （1-4C）烷基，NR'R“，SO2NR'R”或SOmR'; R 1选自H，（1-6C）烷基或 - （CH 2）n L; R 2选自H或 - （CH 2）n L; L是各种取代基，包括苯基，杂环基和杂芳基; n为0-6; m为0-2，R 5选自H，（1-6C）烷基或（1-6C）烷基芳基; R 3选自H或 - （CO）R 6，其中R 6选自多种取代基，包括氢，（1-12C）烷基，吡啶基，苯基，吡啶基（1-12C）烷基 和苯基（1-4C）烷基; 并且R'和R“选自H，（1-4C）烷基，（3-6C）环烷基，苯基（0-4）烷基 - ，杂环（0-4C）烷基 - 或杂芳基（0-4C）烷基 - 含有它们的药物组合物和用于治疗利用它们的神经障碍的方法。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物，C07D451/00至C07D463/00不包括的 |
| --------C07D471/02 | .在稠环系中含两个杂环 |
| ----------C07D471/04 | ..邻位稠环系 |