基本信息:
- 专利标题: CANCER TREATMENT AND METASTASIS PREVENTION
- 专利标题(中):癌症治疗和肿瘤预防
- 申请号:PCT/CA9500259 申请日:1995-04-28
- 公开(公告)号:WO9530423A3 公开(公告)日:1995-12-21
- 发明人: FALK RUDOLF EDGAR , ASCULAI SAMUEL SIMON
- 申请人: NORPHARMCO INC , FALK RUDOLF EDGAR , ASCULAI SAMUEL SIMON
- 专利权人: NORPHARMCO INC,FALK RUDOLF EDGAR,ASCULAI SAMUEL SIMON
- 当前专利权人: NORPHARMCO INC,FALK RUDOLF EDGAR,ASCULAI SAMUEL SIMON
- 优先权: CA2122519 1994-04-29
- 主分类号: A61K31/728
- IPC分类号: A61K31/728 ; A61K9/00 ; A61K31/047 ; A61K31/19 ; A61K31/192 ; A61K31/196 ; A61K31/375 ; A61K31/405 ; A61K31/407 ; A61K31/44 ; A61K31/5415 ; A61K31/715 ; A61K45/06 ; A61K47/00 ; A61K47/36 ; A61P29/00 ; A61P35/00 ; A61P35/04 ; A61K31/725 ; A61K31/495 ; A61K31/70
摘要:
A new method for the treatment of cancer in a human particularly malignant tumors, for example those in a breast or breasts, said method comprising the steps of: (1) directly injecting into the tumour a dosage amount of a pharmaceutical composition comprising an effective amount of an anti-cancer drug and/or drug suitable for use to treat cancer (for example about 1 to about 2 mg Novantrone (Mitoxantrone), other chemotherapeutic agent, NSAIDs) and an effective amount of a form of hyaluronic acid, for example hyaluronic acid and/or pharmaceutically acceptable salts thereof preferably sodium hyaluronate having a molecular weight of less than 750,000 daltons (for example 150,000 - 225,000 daltons) (for example about 10 to about 20 mg sodium hyaluronate) in sterile water; and (2) administering systemically, preferably intravenously, a dosage amount of a pharmaceutical composition comprising: (i) an effective amount of a form of hyaluronic acid (for example hyaluronic acid and/or pharmaceutically acceptable salts thereof, preferably sodium hyaluronate having a molecular weight less than 750,000 daltons (for example 150,000 - 225,000 daltons) for example about 100 - 200 mg or more (because of a lack of toxicity and to reduce the side effects of any medicine (for example NSAID) administered therewith if the amount of the form of hyaluronic acid exceeds about 200 mg/70 kg person); (ii) a drug selected from the group comprising: a) a non-steroidal anti-inflammatory drug (NSAID) for example in an amount of from about 30 mg to about 100 mg (for example 30 to 60 mg of tromethanine salt of ketoralac (sold under the trade mark Toradol) and 50 to 100 mg of diclofenac or diclofenac sodium (for example sold under the trade mark Voltarol), b) an anti-cancer drug, and c) a drug suitable for use to treat cancer and combinations thereof optionally together with (iii) an anti-oxidant for example Vitamin C (in one embodiment 25 gm of Vitamin C).
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/70 | .碳水化合物;糖;其衍生物 |
----------A61K31/7088 | ..含有3个或更多个核苷或核苷酸的化合物 |
------------A61K31/717 | ...纤维素 |
--------------A61K31/728 | ....透明质酸 |