基本信息:
- 专利标题: TAXOL DERIVATIVES
- 专利标题(中):TAXOL衍生物
- 申请号:PCT/US1994007973 申请日:1994-07-15
- 公开(公告)号:WO1995002400A1 公开(公告)日:1995-01-26
- 发明人: ABBOTT LABORATORIES , KLEIN, Larry, L. , MARING, Clarence, J.
- 申请人: ABBOTT LABORATORIES
- 专利权人: ABBOTT LABORATORIES
- 当前专利权人: ABBOTT LABORATORIES
- 优先权: US8/092,124 19930715
- 主分类号: A61K31/335
- IPC分类号: A61K31/335
摘要:
A compound or prodrug thereof having formula (II), wherein -OR comprises the C-13 side-chain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R", -CH=NR', -CH=NOR', -CH=NNR'R", -CH(OH)SO3Na, -CH2OPO3 , -CH2OSO3 , -CN and a radical of formula (a) where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.
摘要(中):
具有式(II)的化合物或前药,其中-OR 1包含紫杉醇的C-13侧链,Z选自-CHO,-CH 2 OH,-CH 2 OR',-CH 2 NR'R “,-CH = NR',-CH = NOR',-CH = NNR'R”,-CH(OH)SO3Na,-CH2OPO3 =,-CH2OSO3 = )其中X和Y独立地选自-O - , - S - 和-N(R') - ,以及制备本发明化合物的方法,其用于抑制肿瘤的方法和 含有该组合物的药物组合物。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |