基本信息:
- 专利标题: ANILINE DERIVATIVES
- 专利标题(中):苯胺衍生物
- 申请号:PCT/EP1994001808 申请日:1994-06-03
- 公开(公告)号:WO1994029291A1 公开(公告)日:1994-12-22
- 发明人: ZENECA LIMITED , ZENECA-PHARMA S.A.
- 申请人: ZENECA LIMITED , ZENECA-PHARMA S.A. , EDWARDS, Philip, Neil
- 专利权人: ZENECA LIMITED,ZENECA-PHARMA S.A.,EDWARDS, Philip, Neil
- 当前专利权人: ZENECA LIMITED,ZENECA-PHARMA S.A.,EDWARDS, Philip, Neil
- 优先权: FR93401442.4 19930607
- 主分类号: C07D309/10
- IPC分类号: C07D309/10
摘要:
The invention concerns an aniline derivative of formula (I) wherein R includes hydrogen and (1-4C)alkyl; R includes hydrogen and (1-4C)alkyl; R is hydrogen or (1-4C)alkyl; X includes a group of the formula CR R wherein R is hydrogen or (1-4C)alkyl and R is hydrogen or (1-4C)alkyl; A includes a direct link to X ; X includes thio and sulphonyl; Ar includes phenylene, which may be optionally substituted; R includes hydrogen and (1-4C)alkyl; and R and R together form a ring having 5 to 6 ring atoms including one oxygen atom, and which ring may bear one, two or three substituents, including methyl alpha to the oxygen atom; or a pharmaceutically acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
摘要(中):
本发明涉及式(I)的苯胺衍生物,其中R 4包括氢和(1-4C)烷基; R 5包括氢和(1-4C)烷基; R 6是氢或(1-4C)烷基; X 3包括式CR 7 R 8的基团,其中R 7是氢或(1-4C)烷基,R 8是氢或(1-4C)烷基; A <1>包括与X <1>的直接链接; X 1包括硫代和磺酰基; Ar包括可以任选取代的亚苯基; R 1包括氢和(1-4C)烷基; 并且R 2和R 3一起形成具有5至6个环原子的环,包括一个氧原子,并且该环可以带有一个,两个或三个取代基,包括氧原子的甲基α; 或其药学上可接受的盐; 其准备过程; 含有它们的药物组合物及其作为5-脂肪氧合酶抑制剂的用途。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D309/00 | 杂环化合物,含六元环,有1个氧原子作为仅有的杂环原子,不和其他环稠合 |
--------C07D309/02 | .环原子间或环原子与非环原子间无双键 |
----------C07D309/04 | ..仅有氢原子、烃基或取代烃基直接连在环碳原子上 |
------------C07D309/10 | ...氧原子 |