发明申请
WO1994020072A1 SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF
审中-公开
基本信息:
- 专利标题： SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF
- 专利标题（中）：固体颗粒，生物体颗粒和制造方法及其用途
- 申请号：PCT/SE1994000185 申请日：1994-03-04
- 公开(公告)号：WO1994020072A1 公开(公告)日：1994-09-15
- 发明人： PHARMACIA AB
- 申请人： PHARMACIA AB , WESTESEN, Kirsten , SIEKMANN, Britta
- 专利权人： PHARMACIA AB,WESTESEN, Kirsten,SIEKMANN, Britta
- 当前专利权人： PHARMACIA AB,WESTESEN, Kirsten,SIEKMANN, Britta
- 优先权： US8/027,501 19930305
- 主分类号： A61K09/10
- IPC分类号： A61K09/10
摘要：
The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agent (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. The emulsification process includes melting of the agent (a lipid and for bioactive agent) and mixing with an aqueous phase (heated to melt temperature). The emulsification is completed by a high-pressure homogenization.
摘要（中）：
本发明在药物，疫苗和其他生物活性剂的给药形式和递送系统方面。 更具体地，本发明涉及主要具有不等式形状的胶体固体脂质颗粒（SLP）的悬浮液的制备，脂质基质处于稳定的多态性修饰以及生物活性剂（PBA）的微米和亚微米颗粒的悬浮液中; 以及这些悬浮液或其冻干物作为递送系统的用途，主要用于肠胃外给药优选水溶性差的生物活性物质，特别是药物，以及它们在化妆品，食品和农产品中的用途。 乳化过程包括将试剂（脂质和生物活性剂）熔融并与水相混合（加热至熔融温度）。 乳化通过高压匀浆完成。