发明申请
WO1994003164A1 INHIBITION AND TREATMENT OF INFECTION BY ENVELOPED VIRUS WITH CALIX(N) ARENE COMPOUNDS
审中-公开
基本信息:
- 专利标题： INHIBITION AND TREATMENT OF INFECTION BY ENVELOPED VIRUS WITH CALIX(N) ARENE COMPOUNDS
- 专利标题（中）：通过含有缬氨酸（N）的化合物的病毒感染的抑制和治疗
- 申请号：PCT/US1993007366 申请日：1993-08-05
- 公开(公告)号：WO1994003164A1 公开(公告)日：1994-02-17
- 发明人： GENELABS TECHNOLOGIES, INC.
- 申请人： GENELABS TECHNOLOGIES, INC. , HWANG, Kou, M. , QI, You, Mao , LIU, Su-Ying , CHOY, William , CHEN, Jen
- 专利权人： GENELABS TECHNOLOGIES, INC.,HWANG, Kou, M.,QI, You, Mao,LIU, Su-Ying,CHOY, William,CHEN, Jen
- 当前专利权人： GENELABS TECHNOLOGIES, INC.,HWANG, Kou, M.,QI, You, Mao,LIU, Su-Ying,CHOY, William,CHEN, Jen
- 优先权： US928,108 19920806; US72,566 19930604
- 主分类号： A61K31/18
- IPC分类号： A61K31/18
摘要：
A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n) arene compound derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituent having a terminal carboxylate, phosphate, or sulfonate groups, including esters and amides which are cleavable (in vivo). The compound may be administered orally, or topically, e.g., for treatment of herpes virus. The invention also includes a method of inhibiting infection by sexually transmitted enveloped viruses, by topically administering to an area of likely sexual contact a composition containing a prophylactically effective amount of a macrocyclic compound such as described above.
摘要（中）：
一种通过向感染部位施用治疗有效量的在其与环的桥接附着物的环位置衍生化的杯状（n）芳烃化合物的方法，所述方法具有极性取代基，所述极性取代基具有 末端羧酸盐，磷酸盐或磺酸盐基团，包括可切割的（体内）的酯和酰胺。 化合物可以口服或局部施用，例如用于治疗疱疹病毒。 本发明还包括通过局部施用可能性接触的区域来抑制性传播的包膜病毒的感染的方法，所述组合物含有预防有效量的如上所述的大环化合物。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/18 | ..磺胺类 |