基本信息:
- 专利标题: 1-HYDROXYALKANAMINE PYRANO(3,4-B)INDOLE DERIVATIVES
- 专利标题(中):1-羟基烷胺吡咯烷(3,4-B)吲哚衍生物
- 申请号:PCT/US1979000256 申请日:1979-04-19
- 公开(公告)号:WO1979001037A1 公开(公告)日:1979-11-29
- 发明人: AMERICAN HOME PROD CORP , ASSELIN A , FAILLI A , DIONNE G , REVESZ C , HUMBER L
- 申请人: AMERICAN HOME PROD CORP
- 专利权人: AMERICAN HOME PROD CORP
- 当前专利权人: AMERICAN HOME PROD CORP
- 优先权: US904081 19780508
- 主分类号: A61K31/40
- IPC分类号: A61K31/40
摘要:
New compounds of formula I (FORMULA) in which R1 is lower alkyl; R2 is hydrogen or lower alkyl; R3 and R4 each independently is hydrogen, lower alkyl halo, nitro, trifluoromethyl or lower alkoxy; R5 and R6 each independently is hydrogen or lower alkyl or R5 and R6 together with the nitrogen atom form a pyrrol-1-yl, piperidino or morpholino ring; R7 is hydrogen or lower alkyl; Alk1 and Alk2 each independently is a straight or branched chain lower alkylene having one to six carbon atoms; and X is oxa or thia, and therapeutically acceptable acid addition salts thereof. The above compounds are diuretic agents, which also possess anti-hypertensive activity. They may be used alone or with other diuretic agents. Pharmaceutical compositions containing the compounds and processes for preparing the compounds are also described.
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |
------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的,例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |