基本信息:
- 专利标题： NOVEL COMPOUND AND APPLICATION THEREOF
- 申请号：US17807731 申请日：2022-06-20
- 公开(公告)号：US20230110095A1 公开(公告)日：2023-04-13
- 发明人： Xueqin Lu , Zhuo Mu , Shengjun Wang , Yanchun Du
- 申请人： Kylonova (Xiamen) Biopharma Co., Ltd.
- 申请人地址： CN Xiamen
- 专利权人： Kylonova (Xiamen) Biopharma Co., Ltd.
- 当前专利权人： Kylonova (Xiamen) Biopharma Co., Ltd.
- 当前专利权人地址： CN Xiamen
- 优先权： CN201910576037.1 20190628,CN201911281389.0 20191213
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K47/54 ; A61K47/55 ; A61P31/20
摘要：
The present invention relates to a novel compound and application thereof in the inhibition of HBV gene expression. The structure of the compound comprises an interfering nucleic acid for inhibiting HBV gene expression, transition points, and delivery chains of the interfering nucleic acid. By means of the delivery chains, two or three N-acetylgalactosamines can be introduced to an antisense strand 3′ end of such siRNA, and two or one N-acetylgalactosamine can be correspondingly introduced to a sense strand 5′ end, the total number of the introduced N-acetylgalactosamines being four. In vitro and in vivo pharmacological experiments prove that such a novel compound can continuously and efficiently inhibit HBV gene expression.
公开/授权文献:
- US11840691B2 Compound and application thereof 公开/授权日：2023-12-12