发明公开
US20230330201A1 COMPOSITIONS FOR USE AS A PROPHYLACTIC AGENT TO THOSE AT RISK OF INFECTION OF TUBERCULOSIS, OR AS SECONDARY AGENTS FOR TREATING INFECTED TUBERCULOSIS PATIENTS
审中-公开
基本信息:
- 专利标题： COMPOSITIONS FOR USE AS A PROPHYLACTIC AGENT TO THOSE AT RISK OF INFECTION OF TUBERCULOSIS, OR AS SECONDARY AGENTS FOR TREATING INFECTED TUBERCULOSIS PATIENTS
- 申请号：US18309555 申请日：2023-04-28
- 公开(公告)号：US20230330201A1 公开(公告)日：2023-10-19
- 发明人： Carlos MARTÍN MONTAÑES , Juan Ignacio AGUILÓ ANENTO , Jesús Ángel GONZALO ASENSIO , Dessislava Vaneva MARINOVA , Santiago UGANDA MAÍZ , Esteban RODRÍGUEZ SÁNCHEZ , Eugenia PUENTES COLORADO , Concepción FERNÁNDEZ ÁLVAREZ-SANTULLANO
- 申请人： UNIVERSIDAD DE ZARAGOZA , BIOFABRI S.L.
- 申请人地址： ES Zaragoza
- 专利权人： UNIVERSIDAD DE ZARAGOZA,BIOFABRI S.L.
- 当前专利权人： UNIVERSIDAD DE ZARAGOZA,BIOFABRI S.L.
- 当前专利权人地址： ES Zaragoza
- 优先权： EP 382097.6 2018.02.19
- 主分类号： A61K39/04
- IPC分类号： A61K39/04 ; A61P37/04 ; C12N1/20
摘要：
The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberucolosis complex, preferably a M. tuberculos clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP− phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM− phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberulosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/002 | .原生动物抗原 |
| ----------A61K39/04 | ..分枝杆菌属如结核杆菌 |