发明申请
US20230010288A1 RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES
有权
基本信息:
- 专利标题： RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES
- 申请号：US17371182 申请日：2021-07-09
- 公开(公告)号：US20230010288A1 公开(公告)日：2023-01-12
- 发明人： Kallanthottathil G. Rajeev , Tracy Zimmermann , Muthiah Manoharan , Martin A. Maier , Satyanarayana Kuchimanchi , Klaus Charisse
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/7125 ; A61K31/713 ; C07H21/02
摘要：
The present invention provides RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene and methods of using such RNAi agents for treating or preventing TTR-associated diseases.