基本信息:
- 专利标题： cfDNA CLASSIFICATION METHOD, APPARATUS AND APPLICATION
- 申请号：US17609036 申请日：2020-04-29
- 公开(公告)号：US20220336043A1 公开(公告)日：2022-10-20
- 发明人： Weimin CI , Guangzhe GE , Yuanyuan ZHOU , Xuesong LI
- 申请人： Beijing Institute of Genomics,Chinese Academy of Sciences (China National Center for Bioinformation) , Peking University First Hospital
- 申请人地址： CN Beijing; CN Beijing
- 专利权人： Beijing Institute of Genomics,Chinese Academy of Sciences (China National Center for Bioinformation),Peking University First Hospital
- 当前专利权人： Beijing Institute of Genomics,Chinese Academy of Sciences (China National Center for Bioinformation),Peking University First Hospital
- 当前专利权人地址： CN Beijing; CN Beijing
- 优先权： CN201910374094.1 20190507
- 国际申请： PCT/CN2020/087830 WO 20200429
- 主分类号： G16B20/00
- IPC分类号： G16B20/00 ; C12Q1/6886 ; G16B30/00 ; G16B40/20 ; G16H50/70 ; G16H70/60
摘要：
The invention pertains to the field of genomics and bioinformatics, and relates to a cfDNA classification method, apparatus and application. Specifically, the present invention relates to a cfDNA classification method, comprising: calculating a copy number variation data of cfDNA in a target sample; calculating a similarity degree between the target cfDNA copy number variation data and the cfDNA copy number variation data of each category label; and determining the category to which the target cfDNA belongs according to the similarity degree by using a classifier model. The invention can realize the diagnosis of up to 3 types of urogenital system tumors at one time, and has high sensitivity and specificity. In particular, in the diagnosis and dynamic monitoring of urothelial cancer, the sensitivity and specificity are higher than those of the current clinical detection methods.