A system for removing long-chain and short-chain per- and polyfluoroalkyl substances (PFAS) from contaminated water using a regenerable anion exchange resin includes at least one first anion exchange resin vessel configured to receive a flow of water contaminated with long and short-chain PFAS compounds. The at least one first anion exchange resin vessel includes a first regenerable anion exchange resin therein having a high affinity for long-chain PFAS compounds configured such that a majority of the long-chain PFAS compounds sorb to the first regenerable anion exchange resin to remove a majority of the long-chain PFAS compounds from the contaminated water and produce a flow of water having a majority of the long-chain PFAS compounds removed. The system also includes at least one second anion exchange resin vessel configured to receive the flow of water having a majority of the long-chain PFAS compounds removed. The at least one second anion exchange resin vessel includes a second regenerable anion exchange resin therein having a high affinity for short-chain PFAS compounds and is configured such that a majority of the short-chain PFAS compounds sorb to the second anion exchange resin to remove a majority of the short-chain PFAS compounds from the contaminated water and produce a treated flow of water having a majority of the long and short-chain PFAS compounds removed.