发明申请
US20220218242A1 METHODS AND APPARATUS FOR MAKING A DETERMINATION ABOUT A PRESENCE OR AN ABSENCE OF A PARASITE IN A BLOOD SAMPLE
有权
基本信息:
- 专利标题： METHODS AND APPARATUS FOR MAKING A DETERMINATION ABOUT A PRESENCE OR AN ABSENCE OF A PARASITE IN A BLOOD SAMPLE
- 申请号：US17614879 申请日：2020-05-29
- 公开(公告)号：US20220218242A1 公开(公告)日：2022-07-14
- 发明人： Vishwanath SUBRAMANIAM , Mark DREW , Jonathan KADOWAKI , Travis JONES , Joseph WEST , Marcel YOTEBIENG , Shaurya PRAKASH , Alexander SCARMUZZI , Redi LLAPI , Jack CROWLEY , Sandra METZLER
- 申请人： Ohio State Innovation Foundation
- 申请人地址： US OH Columbus
- 专利权人： Ohio State Innovation Foundation
- 当前专利权人： Ohio State Innovation Foundation
- 当前专利权人地址： US OH Columbus
- 国际申请： PCT/US2020/035095 WO 20200529
- 主分类号： A61B5/145
- IPC分类号： A61B5/145 ; A61B5/00 ; G16H50/20
摘要：
Disclosed herein are methods and apparatus for making a determination whether a blood sample is, or is not, infected with a malaria parasite. The determination is made using a trained machine-learning (ML) algorithm. In some aspects, a microfluidic chip is used for the concentration of red blood cells infected with these parasites from uninfected red blood cells, the staining of the blood sample which differentially stains infected and uninfected red blood cells, and holds the sample of interest for imaging. The microfluidic chip is inserted into an optical subsystem that magnifies the image created from transmitted light microscopy. The magnified image is captured with a camera, and a trained ML algorithm assesses if the sample does or does not contain the parasite. Generally, the ML algorithm is executed on a portable computing device such as a smartphone.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61B | 诊断；外科；鉴定 |
| ------A61B5/00 | 用于诊断目的的测量；人的辨识 |
| --------A61B5/145 | .测量体内血液特性，例如，气体浓度、pH值 |