发明申请
US20220170073A1 METHODS AND/OR USE OF OLIGONUCLEOTIDE CONJUGATES FOR ASSAYS AND FLOW CYTOMETRY DETECTIONS
有权
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基本信息:
- 专利标题: METHODS AND/OR USE OF OLIGONUCLEOTIDE CONJUGATES FOR ASSAYS AND FLOW CYTOMETRY DETECTIONS
- 申请号:US17369771 申请日:2021-07-07
- 公开(公告)号:US20220170073A1 公开(公告)日:2022-06-02
- 发明人: David A. Schwartz , Jimmy Williams , Xinfang Zhao , Chunfang Zhao , William B. Busa , Stephen J. Kron , Amy Catherine Flor
- 申请人: The University of Chicago , EMD Millipore Corporation
- 申请人地址: US IL Chicago; US MA Burlington
- 专利权人: The University of Chicago,EMD Millipore Corporation
- 当前专利权人: The University of Chicago,EMD Millipore Corporation
- 当前专利权人地址: US IL Chicago; US MA Burlington
- 主分类号: C12Q1/6804
- IPC分类号: C12Q1/6804 ; C07H21/00 ; C12Q1/6834
摘要:
The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.