发明申请
US20220162257A1 3ALPHA, 5BETA-NEUROACTIVE STEROIDS FOR THE TREATMENT OF EPILEPSY AND SEIZURE DISEASES
有权
基本信息:
- 专利标题： 3ALPHA, 5BETA-NEUROACTIVE STEROIDS FOR THE TREATMENT OF EPILEPSY AND SEIZURE DISEASES
- 申请号：US17439688 申请日：2020-04-02
- 公开(公告)号：US20220162257A1 公开(公告)日：2022-05-26
- 发明人： Eva KUDOVA , Hana CHODOUNSKA , Pavel MARES , Karel VALES
- 申请人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. , FYZIOLOGICKY USTAV AV CR, V. V. I.
- 申请人地址： CZ Praha 6; CZ Praha 4
- 专利权人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I.,FYZIOLOGICKY USTAV AV CR, V. V. I.
- 当前专利权人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I.,FYZIOLOGICKY USTAV AV CR, V. V. I.
- 当前专利权人地址： CZ Praha 6; CZ Praha 4
- 优先权： CZPV2019-216 20190405
- 国际申请： PCT/CZ2020/050017 WO 20200402
- 主分类号： C07J43/00
- IPC分类号： C07J43/00 ; A61P25/08 ; A61P25/28 ; A61P25/18 ; C07J41/00
摘要：
3α5β-steroid compounds of general formula I is disclosed. These compounds are useful in the treatment of epilepsy or comorbidities associated with epilepsy or conditions associated with convulsions, such as seizures associated with hypoxia, seizures associated with traumatic brain damage, seizures associated with intoxication, pathological changes caused by hyperexcitation, or in treatment of conditions accompanying epilepsy, such as affective disorders, depression, post-traumatic stress disorder (PTSD) and stress-related diseases, anxiety, schizophrenia and psychotic disorders, related ischemic CNS damage, neurodegenerative changes and disorders, multiple sclerosis. The compounds of general formula I also show age-specific efficacy.