基本信息:
- 专利标题： NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST
- 申请号：US17506497 申请日：2021-10-20
- 公开(公告)号：US20220144784A1 公开(公告)日：2022-05-12
- 发明人： Takuya IKEDA , Yoshiyuki KOBAYASHI , Naoki MIYOSHI , Osamu SUZUKI , Takahiro NAGAYAMA , Takashi TSUJI , Layton H. SMITH , Anthony B. PINKERTON
- 申请人： Sanford Burnham Prebys Medical Discovery Institute
- 申请人地址： US CA La Jolla
- 专利权人： Sanford Burnham Prebys Medical Discovery Institute
- 当前专利权人： Sanford Burnham Prebys Medical Discovery Institute
- 当前专利权人地址： US CA La Jolla
- 主分类号： C07D249/12
- IPC分类号： C07D249/12 ; G16B25/00 ; G16C99/00 ; C07D403/12 ; C07D403/06 ; G16C20/50 ; A61P9/10 ; A61P3/10 ; A61P9/12 ; A61P13/12 ; A61P9/04 ; C07D401/04 ; C07D405/04 ; C07D405/14 ; C07D409/04 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D487/04
摘要：
The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —N═ or —CH═, X2 represents —CH═ or —N═, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.
公开/授权文献:
- US12071413B2 Azole derivatives as apelin receptor agonist 公开/授权日：2024-08-27
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D249/00 | 杂环化合物，含五元环，有3个氮原子作为仅有的杂环原子 |
| --------C07D249/02 | .不与其他环稠合 |
| ----------C07D249/04 | ..1,2,3-三唑；氢化1,2,3-三唑 |
| ------------C07D249/10 | ...有杂原子或有以3个键连接杂原子，其中最多以1个键连接卤素的碳原子，例如酯基或腈基，直接连在环碳原子上 |
| --------------C07D249/12 | ....氧或硫原子 |