发明申请
US20220119549A1 SHIELDED BIOLOGICS WITH MASKING DOMAINS TO SHIELD ANTIGEN BINDING CAPABILITY OF BIOLOGICS AND USES THEREOF
有权
基本信息:
- 专利标题： SHIELDED BIOLOGICS WITH MASKING DOMAINS TO SHIELD ANTIGEN BINDING CAPABILITY OF BIOLOGICS AND USES THEREOF
- 申请号：US17501036 申请日：2021-10-14
- 公开(公告)号：US20220119549A1 公开(公告)日：2022-04-21
- 发明人： Di ZHANG , Lihua SHI , Minseon CHO , Motohiko NISHIDA , Man-Cheong FUNG , Mark CHIU
- 申请人： Tavotek Biotherapeutics (Hong Kong) Limited
- 申请人地址： HK Shung Wan
- 专利权人： Tavotek Biotherapeutics (Hong Kong) Limited
- 当前专利权人： Tavotek Biotherapeutics (Hong Kong) Limited
- 当前专利权人地址： HK Shung Wan
- 主分类号： C07K16/32
- IPC分类号： C07K16/32 ; C12N15/63 ; C07K16/24 ; A61P35/00
摘要：
The present disclosure relates to a shielded biologic with a masking domain, e.g., based on Insulin-like Growth Factor 2 (IGF2), fused to the Fab domain of an antibody via protease-cleavable linker to mask the antigen binding capability of the antibody, and to the use of said shielded biologic for effective and site-specific disease treatment while reducing systematic toxicity.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/32 | ..抗致肿瘤基因的转移产物 |