基本信息:
- 专利标题： METHODS FOR PREDICTING ACUTE SEVERE COLITIS TREATMENT RESPONSE
- 申请号：US17340534 申请日：2021-06-07
- 公开(公告)号：US20220098665A1 公开(公告)日：2022-03-31
- 发明人： Eric OGIER-DENIS , Xavier TRETON , Yoram BOUHNIK , Ian MORILLA , David LAHARIE , Gilles WAINRIB , Mathieu UZZAN
- 申请人： INSERM (Institut National de la Sante et de la Recherche Medicale , Universite de Paris , Assistance Publique-Hopitaux de Paris (APHP) , Universite de Bordeaux , CHU de Bordeaux , Universite Paris XIII Paris-Nord
- 申请人地址： FR Paris; FR Paris; FR Paris; FR Bordeaux; FR Talence; FR Villetaneuse
- 专利权人： INSERM (Institut National de la Sante et de la Recherche Medicale,Universite de Paris,Assistance Publique-Hopitaux de Paris (APHP),Universite de Bordeaux,CHU de Bordeaux,Universite Paris XIII Paris-Nord
- 当前专利权人： INSERM (Institut National de la Sante et de la Recherche Medicale,Universite de Paris,Assistance Publique-Hopitaux de Paris (APHP),Universite de Bordeaux,CHU de Bordeaux,Universite Paris XIII Paris-Nord
- 当前专利权人地址： FR Paris; FR Paris; FR Paris; FR Bordeaux; FR Talence; FR Villetaneuse
- 优先权： EP16305715.1 20160614
- 主分类号： C12Q1/6883
- IPC分类号： C12Q1/6883 ; G16B40/00 ; C07K16/24
摘要：
The present invention relates to methods for predicting acute severe colitis treatment response. Currently, there is no biomarker of drag response. The present invention provides the first prediction tool for responses to first- and second-line treatments in acute severe ulcerative colitis. Putative mRNA targets of dysregulated microRNAs were identified from patient biopsies. One classifier of fifteen colonic microRNAs plus five biological values at admission were identified with a prediction accuracy of 96.6% for discriminating responders from non-responders to steroids. Using a similar method, 6 and 4 mucosal microRNA-based algorithms were identified to classify responders from non-responders to infliximab and cyclosporine. In particular, the present invention relates to methods for predicting acute severe colitis treatment response by measuring the expression levels of several miRNAs selected front the group consisting of hp_hsa-mir-3934, hp_hsa-mir-100, hsa-miR-718, hp_hsa-mir-193b, hsa-miR-3150a-5p, hp_hsa-mir-1260b, hsa-miR-938, hsa-miR-518b and hsa-miR-1468.
IPC结构图谱:
| C | 化学；冶金 |
| --C12 | 生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程 |
| ----C12Q | 包含酶或微生物的测定或检验方法；其所用的组合物或试纸；这种组合物的制备方法；在微生物学方法或酶学方法中的条件反应控制 |
| ------C12Q1/00 | 包含酶或微生物的测定或检验方法；其组合物；这种组合物的制备方法 |
| --------C12Q1/68 | .包括核酸 |
| ----------C12Q1/6813 | ..杂交分析 |
| ------------C12Q1/6883 | ...用于由遗传物质改变而引起的疾病 |