基本信息:
- 专利标题： MULTI-PEG LIPID COMPOUNDS
- 申请号：US17291923 申请日：2019-11-07
- 公开(公告)号：US20220016029A1 公开(公告)日：2022-01-20
- 发明人： Shrirang Karve , Yi Zhang , Frank DeRosa , Michael Heartlein
- 申请人： Translate Bio, Inc.
- 申请人地址： US MA Lexington
- 专利权人： Translate Bio, Inc.
- 当前专利权人： Translate Bio, Inc.
- 当前专利权人地址： US MA Lexington
- 国际申请： PCT/US19/60335 WO 20191107
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; C08G65/333 ; C08G65/332 ; C08G65/335 ; A61K45/06
摘要：
The compounds disclosed herein (e.g., compounds of Formula (I), (II), (III), and (IV)) comprise a lipid substructure comprising a hydrophobic moiety and a hydrophilic moiety; and two or more polymeric groups (e.g., two or more polyethylene glycol (PEG) groups). The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/127 | ..脂质体 |