基本信息:
- 专利标题： MODIFIED DOUBLE STRANDED OLIGONUCLEOTIDE
- 申请号：US17291775 申请日：2019-11-05
- 公开(公告)号：US20210388356A1 公开(公告)日：2021-12-16
- 发明人： Donald FOSTER , Mark K. SCHLEGEL , Christopher BROWN
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2019/059818 WO 20191105
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.