基本信息:
- 专利标题： APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
- 申请号：US17180997 申请日：2021-02-22
- 公开(公告)号：US20210292756A1 公开(公告)日：2021-09-23
- 发明人： Frederic Tremblay , Lucas D. BonDurant , James D. McIninch , Adam Castoreno , Mark K. Schlegel , Charalambos Kaittanis
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the apolipoprotein C3 gene (APOC3). The invention also relates to methods of using such RNAi agents to inhibit expression of an APOC3 gene and to methods of preventing and treating an APOC3-associated disorder, e.g., hypertriglyceridemia, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, polycystic ovary syndrome, kidney disease, obesity, type 2 diabetes mellitus (insulin resistance), hypertension, artherosclerosis and pancreatitis.