发明申请
US20210128676A1 METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1 AND LOW MEAN ARTERIAL PRESSURE
有权
基本信息:
- 专利标题： METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1 AND LOW MEAN ARTERIAL PRESSURE
- 申请号：US17083409 申请日：2020-10-29
- 公开(公告)号：US20210128676A1 公开(公告)日：2021-05-06
- 发明人： Khurram Jamil , Stephen Chris Pappas , Peter Teuber
- 申请人： Mallinckrodt Hospital Products IP Unlimited Company
- 申请人地址： IE Dublin 15
- 专利权人： Mallinckrodt Hospital Products IP Unlimited Company
- 当前专利权人： Mallinckrodt Hospital Products IP Unlimited Company
- 当前专利权人地址： IE Dublin 15
- 主分类号： A61K38/095
- IPC分类号： A61K38/095 ; A61K38/38
摘要：
The principles and embodiments of the present disclosure relate to methods of increasing survival of a patient having type 1 hepatorenal syndrome (HRS-1) and low mean arterial pressure (MAP). The methods may include identifying a patient having HRS-1 that has a baseline MAP of less than 65 mmHg, and administering, to the patient, an amount of terlipressin effective to treat the HRS-1 in the patient. In other aspects, the method may include administering an effective dose of terlipressin to a patient in need thereof every 6 hours by intravenous (IV) bolus injection over 2 minutes, where the dose is sufficient to yield an increase in MAP and decrease in heart rate in the patient. The patient may not have overt sepsis, septic shock, or uncontrolled infection.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/04 | .在完全确定的序列中最多有20个氨基酸的肽；其衍生物 |
| ----------A61K38/095 | ..催产素；血管加压素；相关的肽 |