基本信息:
- 专利标题： OLIGONUCLEOTIDES COMPRISING ACYCLIC AND ABASIC NUCLEOSIDES AND ANALOGS
- 申请号：US17111096 申请日：2020-12-03
- 公开(公告)号：US20210087219A1 公开(公告)日：2021-03-25
- 发明人： Muthiah MANOHARAN , Kallanthottathil G. RAJEEV , Jeremy LACKEY , Jayaprakash K. NAIR
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/00 ; C07F9/6512 ; C07F9/655 ; C07F9/6558 ; C07H19/20
摘要：
This invention relates to an oligonucleotide comprising one or more abasic nucleoside monomers of formula IV′: These monomers are useful for modifying of oligonucleotides at one or more positions. This invention also relates to a method of inhibiting the expression of a target gene in a cell. The method comprises contacting the cell with an oligonucleotide having one or more of the above formula (IV′).
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07H | 糖类；及其衍生物；核苷；核苷酸；核酸 |
| ------C07H21/00 | 含有两个或多个单核苷酸单元的化合物，具有以核苷基的糖化物基团连接的单独的磷酸酯基或多磷酸酯基，例如核酸 |
| --------C07H21/02 | .以核糖基作为糖化物基团 |