基本信息:
- 专利标题： INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30
- 申请号：US16753439 申请日：2018-10-05
- 公开(公告)号：US20200317658A1 公开(公告)日：2020-10-08
- 发明人： Justin Caravella , Bingsong Han , Cuixian Liu , Stephanos Ioannidis , Alexandre Joseph Buckmelter , David James Richard , Matthew W. Martin , Steven Mischke , Scot Mente
- 申请人： FORMA Therapeutics, Inc.
- 国际申请： PCT/US2018/054520 WO 20181005
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D417/04 ; C07D277/56 ; C07D231/40 ; C07D277/46 ; C07C261/04 ; C07D241/04 ; C07D265/30
摘要：
The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments.
公开/授权文献:
- US11247987B2 Inhibiting ubiquitin specific peptidase 30 公开/授权日：2022-02-15
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D417/00 | 杂环化合物，含两个或更多个杂环、至少有1个环有氮原子和硫原子作为仅有的杂环原子，C07D415/00组不包含的 |
| --------C07D417/02 | .含有两个杂环 |
| ----------C07D417/12 | ..被含有杂原子的链作为键链连接的 |