发明申请
US20200283364A1 GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM
审中-公开
基本信息:
- 专利标题： GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM
- 申请号：US16632592 申请日：2018-07-19
- 公开(公告)号：US20200283364A1 公开(公告)日：2020-09-10
- 发明人： Youngjoo BYUN , Hee-Deung PARK , Sang-Hyun SON , Eunji CHA , So-Young HAM , Hyunsuk CHOI
- 申请人： Korea University Research and Business Foundation, Sejong Campus , Korea University Research and Business Foundation
- 申请人地址： KR Sejong KR Seoul
- 专利权人： Korea University Research and Business Foundation, Sejong Campus,Korea University Research and Business Foundation
- 当前专利权人： Korea University Research and Business Foundation, Sejong Campus,Korea University Research and Business Foundation
- 当前专利权人地址： KR Sejong KR Seoul
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@619aa518 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@73e8f45
- 国际申请： PCT/KR2018/008171 WO 20180719
- 主分类号： C07C49/255
- IPC分类号： C07C49/255 ; C07C49/245 ; A61P31/04
摘要：
The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C49/00 | 酮；乙烯酮；二聚乙烯酮；酮的螯合物 |
| --------C07C49/04 | .有酮基连接在非环碳原子上的饱和化合物 |
| ----------C07C49/255 | ..含醚基、COOC基、COOCOC基或COOCOCOC基 |