基本信息:
- 专利标题： HUMANIZED ANTIBODIES AGAINST CEACAM1
- 申请号：US16876726 申请日：2020-05-18
- 公开(公告)号：US20200277398A1 公开(公告)日：2020-09-03
- 发明人： Tehila BEN-MOSHE , Yair SAPIR , Ilana MANDEL , Gal MARKEL , Jacob SCHACHTER , Rona ORTENBERG , Francis Joseph CARR , Robert George E. HOLGATE , Timothy David JONES
- 申请人： Famewave Ltd.
- 申请人地址： IL Tel Aviv
- 专利权人： Famewave Ltd.
- 当前专利权人： Famewave Ltd.
- 当前专利权人地址： IL Tel Aviv
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; G01N33/574 ; A61K45/06 ; C07K16/28 ; A61K39/395 ; A61K35/17
摘要：
Humanized antibodies, capable of specific binding to human CEACAM1 molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.
公开/授权文献:
- US11866509B2 Humanized antibodies against CEACAM1 公开/授权日：2024-01-09
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |
| ------------C07K16/30 | ...来自肿瘤细胞 |