发明申请
US20200270359A1 BISPECIFIC ANTI-CD37 ANTIBODIES, MONOCLONAL ANTI-CD37 ANTIBODIES AND METHODS OF USE THEREOF
审中-公开
基本信息:
- 专利标题： BISPECIFIC ANTI-CD37 ANTIBODIES, MONOCLONAL ANTI-CD37 ANTIBODIES AND METHODS OF USE THEREOF
- 申请号：US16498104 申请日：2018-04-03
- 公开(公告)号：US20200270359A1 公开(公告)日：2020-08-27
- 发明人： Simone OOSTINDIE , Frank BEURSKENS , Esther BREIJ , Edward VAN DEN BRINK , Andreas HOLLENSTEIN , Marije OVERDIJK , Margaret LINDORFER , Ronald TAYLOR , Paul PARREN , Hilma VAN DER HORST , Martine E.D. CHAMULEAU , Tuna MUTIS
- 申请人： GENMAB HOLDING B.V.
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@51011979
- 国际申请： PCT/EP2018/058479 WO 20180403
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; G01N33/68 ; A61K49/00 ; A61P35/00
摘要：
CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |