基本信息:
- 专利标题： MACROCYCLIC INDOLE DERIVATIVES
- 申请号：US16301871 申请日：2017-05-17
- 公开(公告)号：US20200087322A1 公开(公告)日：2020-03-19
- 发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Fernandez-Montalvan , Nicolas Werbeck , Ursula Moenning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick R. McCarren
- 申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc.
- 优先权： EP16172726.8 20160602
- 国际申请： PCT/EP2017/000629 WO 20170517
- 主分类号： C07D498/16
- IPC分类号： C07D498/16 ; C07D487/16 ; C07D498/22 ; C07D498/06
摘要：
The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
公开/授权文献:
- US10981932B2 Macrocyclic indole derivatives 公开/授权日：2021-04-20
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D498/00 | 杂环化合物，在稠环系中至少有1个杂环具有氮和氧原子作为仅有的杂环原子 |
| --------C07D498/02 | .在稠环系中含有两个杂环 |
| ----------C07D498/16 | ..迫位稠合系 |