基本信息:
- 专利标题： METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS
- 申请号：US16431099 申请日：2019-06-04
- 公开(公告)号：US20200046826A1 公开(公告)日：2020-02-13
- 发明人： Chi-Huey Wong , Che Ma , Cheng-Chi Wang , Juine-Ruey Chen
- 申请人： Academia Sinica
- 申请人地址： TW Taipei
- 专利权人： Academia Sinica
- 当前专利权人： Academia Sinica
- 当前专利权人地址： TW Taipei
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; A61K39/12 ; C07K16/10 ; C12N7/00
摘要：
Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.
公开/授权文献:
- US11672853B2 Methods and compositions for immunization against virus 公开/授权日：2023-06-13
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/12 | .病毒性抗原 |
| ----------A61K39/145 | ..正黏液病毒科，例如流感病毒属 |