发明申请
US20200015741A1 METHOD OF MEASURING EFFICACY OF TREATMENT FOR AN AUTOIMMUNE DISEASE IN VIVARIUM ANIMALS
审中-公开
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基本信息:
- 专利标题: METHOD OF MEASURING EFFICACY OF TREATMENT FOR AN AUTOIMMUNE DISEASE IN VIVARIUM ANIMALS
- 申请号:US16578298 申请日:2019-09-21
- 公开(公告)号:US20200015741A1 公开(公告)日:2020-01-16
- 发明人: Laura Schaevitz , Daniel J. Ford
- 申请人: Vium, Inc.
- 申请人地址: US CA San Mateo
- 专利权人: Vium, Inc
- 当前专利权人: Vium, Inc
- 当前专利权人地址: US CA San Mateo
- 主分类号: A61B5/00
- IPC分类号: A61B5/00 ; A61B5/11 ; A01K1/03 ; A01K29/00
摘要:
A method of measuring efficacy of test treatment of an autoimmune disease in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals, a standard of care or a reference treatment for the first disease to determine efficacy of the test treatment. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Other embodiment uses a Fourier transform on a circle, LASSO, RANSAC or regression analyses for curve fitting. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.
公开/授权文献:
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61B | 诊断;外科;鉴定 |
------A61B5/00 | 用于诊断目的的测量;人的辨识 |