发明申请
US20190328896A1 SELECTIVE UV CROSSLINKING OF PEPTIDES AND FUNCTIONAL MOIETIES TO IMMUNOGLOBULINS
审中-公开
基本信息:
- 专利标题： SELECTIVE UV CROSSLINKING OF PEPTIDES AND FUNCTIONAL MOIETIES TO IMMUNOGLOBULINS
- 申请号：US16450615 申请日：2019-06-24
- 公开(公告)号：US20190328896A1 公开(公告)日：2019-10-31
- 发明人： Zihni Basar BILGICER , Nathan J. ALVES
- 申请人： University of Notre Dame du Lac
- 申请人地址： US IN South Bend
- 专利权人： University of Notre Dame du Lac
- 当前专利权人： University of Notre Dame du Lac
- 当前专利权人地址： US IN South Bend
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07K16/00 ; C07K16/28 ; G01N33/531 ; G01N33/532 ; G01N33/533 ; G01N33/543 ; A61K31/337
摘要：
A method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/50 | .非有效成分被化学键合到有效成分上，例如聚合物－药物结合物 |
| ----------A61K47/66 | ..该改性剂是靶向特定细胞的涉及肽或蛋白质的预靶向系统 |
| ------------A61K47/68 | ...该改性剂是抗体、免疫球蛋白或其片段，例如Fc-片段 |