基本信息:
- 专利标题： Method for Determining the Haemoglobin F Content of an Erythroid Cell
- 申请号：US16347738 申请日：2017-11-03
- 公开(公告)号：US20190265255A1 公开(公告)日：2019-08-29
- 发明人： Marie CAMBOT , Gaetana VANDEMEULEBROUCK , France NOIZAT PIRENNE , Pablo BARTOLUCCI , Marie Georgine RAKOTOSON , Frédéric GALACTEROS
- 申请人： UNIVERSITE PARIS EST CRETEIL VAL DE MARNE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT NATIONAL TRANSFUSION SANGUINE , ETABLISSEMENT FRANCAIS DU SANG , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
- 优先权： FR1660713 20161104
- 国际申请： PCT/FR2017/053015 WO 20171103
- 主分类号： G01N33/72
- IPC分类号： G01N33/72 ; G01N15/14 ; G01N33/80
摘要：
The invention concerns a method for determining, by flow cytometry, the hemoglobin F (HbF) content of each erythroid cell of a set of erythroid cells. This method applies in particular to determining the HbF content of each red blood cell of a set of red blood cells. The invention also concerns a method for determining the amount of red blood cells transfused into a patient and for monitoring the therapeutic efficacy of a treatment for sickle cell disease or β-thalassemia.