![Adoptive T-Cell Therapy](/abs-image/US/2019/07/18/US20190216908A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: Adoptive T-Cell Therapy
- 申请号:US16314117 申请日:2017-06-30
- 公开(公告)号:US20190216908A1 公开(公告)日:2019-07-18
- 发明人: Christian Klein , Claudio Sustmann , Gerhard Niederfellner , Martina Geiger , Stefan Endres , Sebastian Kobold
- 申请人: Hoffmann-La Roche Inc. , Ludwig-Maximilians-Universitat Munchen
- 优先权: EP16177203.3 20160630
- 国际申请: PCT/EP2017/066375 WO 20170630
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K39/395 ; C07K16/30 ; A61P35/00 ; C07K16/28
摘要:
The present invention generally relates to T-cells, such as CD8+ T-cells, CD4+ T-cells, CD3+ T-cells, γδ T-cells or natural killer (NK) T-cells, transfected/transduced with a fusion protein which is recruited by the use of trivalent, bispecific antibody molecule which specifically binds to/interacts with the extracellular domain of the fusion protein. More precisely, the present invention relates to a kit comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention and the trivalent, bispecific antibody molecules of the present invention. Further aspects of the inventions are expression vectors comprising nucleic acid molecules encoding the fusion proteins as well as the trivalent, bispecific antibody molecules. Further, a process for the production of the trivalent, bispecific antibody molecules of the invention and a medicament/pharmaceutical composition comprising said trivalent, bispecific antibody molecules are described. The invention also provides the use of said trivalent, bispecific antibody molecules in a method for the treatment of particular diseases as well as a pharmaceutical compositions/medicament comprising said trivalent, bispecific antibody molecules, wherein said trivalent, bispecific antibody molecule(s) is (are) to be administered in combination with transduced T-cells comprising the fusion protein of the invention. The invention also provides a method for the treatment of particular diseases.
公开/授权文献:
- US11547748B2 Adoptive t-cell therapy 公开/授权日:2023-01-10
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K39/00 | 含有抗原或抗体的医药配制品 |