发明申请
US20190203228A1 VIRAL PARTICLE FOR THE TRANSFER OF RNAs, ESPECIALLY INTO CELLS INVOLVED IN IMMUNE RESPONSE
审中-公开
基本信息:
- 专利标题： VIRAL PARTICLE FOR THE TRANSFER OF RNAs, ESPECIALLY INTO CELLS INVOLVED IN IMMUNE RESPONSE
- 申请号：US16301354 申请日：2017-05-12
- 公开(公告)号：US20190203228A1 公开(公告)日：2019-07-04
- 发明人： Pascale BOUILLE , Christine DUTHOIT , Lucille LAMOUROUX
- 申请人： FLASH THERAPEUTICS
- 申请人地址： FR Toulouse
- 专利权人： Flash Therapeutics
- 当前专利权人： Flash Therapeutics
- 当前专利权人地址： FR Toulouse
- 优先权： FR1654333 20160513; FR1752819 20170331
- 国际申请： PCT/FR2017/051165 WO 20170512
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C07K14/16
摘要：
The present invention relates to retroviral particle comprising a protein derived from the Gag polyprotein, an envelope protein, optionally an integrase and at least two encapsidated non-viral RNAs, the encapsidated non-viral RNAs each comprising an RNA sequence of interest bound to an encapsidation sequence, each encapsidation sequence being recognized by a binding domain introduced into the protein derived from the Gag polyprotein and/or into the integrase, and at least one of said sequences of interest of the encapsidated non-viral RNAs comprises a part coding at least one epitope and/or at least one molecular structure specifically recognizing an epitope.