发明申请
US20190192561A1 COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
审中-公开
基本信息:
- 专利标题： COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
- 申请号：US16291477 申请日：2019-03-04
- 公开(公告)号：US20190192561A1 公开(公告)日：2019-06-27
- 发明人： Samuel Strober , Robert Lowsky
- 申请人： The Board of Trustees of the Leland Stanford Junior University
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61K35/22 ; A61K35/28 ; A61K39/395 ; A61N5/10 ; A61K38/13 ; A61K31/573 ; A61K31/436 ; A61K45/06 ; A61K41/00 ; A61K38/19 ; A61K35/14 ; A61K35/17 ; A61K39/00 ; A61K31/365
摘要：
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |
| --------A61K35/12 | .来源于哺乳动物或鸟类的材料的 |