基本信息:
- 专利标题： NOVEL BISPECIFIC POLYPEPTIDES AGAINST CD137
- 申请号：US16094127 申请日：2017-04-24
- 公开(公告)号：US20190169308A1 公开(公告)日：2019-06-06
- 发明人： Eva Dahlén , Peter Ellmark , Christina Furebring , Per Norlén , Anna Säll , Laura von Schantz , Niina Veitonmäki , Laura Varas , Jessica Petersson , Sara Fritzell
- 申请人： ALLIGATOR BIOSCIENCE AB
- 优先权： GB1607046.8 20160422
- 国际申请： PCT/EP2017/059656 WO 20170424
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K39/395 ; C07K16/28
摘要：
The invention provides bispecific polypeptides comprising a first binding domain, designated B1, which is capable of binding specifically to CD137, and a second binding domain, designated B2, which is capable of specifically binding to a tumour cell-associated antigen. Also provided are pharmaceutical compositions of such bispecific polypeptides and uses of the same in medicine.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |
| ------------C07K16/30 | ...来自肿瘤细胞 |