基本信息:
- 专利标题： DRUG COMPOUND AND PURIFICATION METHODS THEREOF
- 申请号：US16053354 申请日：2018-08-02
- 公开(公告)号：US20190085018A1 公开(公告)日：2019-03-21
- 发明人： Rajashree JOSHI-HANGAL , Nipun DAVAR , Stephen R. PRIEBE
- 申请人： Otsuka Pharmaceutical Co., Ltd.
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07H19/173
摘要：
The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.
公开/授权文献:
- US10519190B2 Drug compound and purification methods thereof 公开/授权日：2019-12-31
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07H | 糖类；及其衍生物；核苷；核苷酸；核酸 |
| ------C07H21/00 | 含有两个或多个单核苷酸单元的化合物，具有以核苷基的糖化物基团连接的单独的磷酸酯基或多磷酸酯基，例如核酸 |
| --------C07H21/04 | .以脱氧核糖基作为糖化物基团 |