基本信息:
- 专利标题： ANTI-HUMAN 4-1BB ANTIBODIES AND USES THEREOF
- 申请号：US16191381 申请日：2018-11-14
- 公开(公告)号：US20190071510A1 公开(公告)日：2019-03-07
- 发明人： Byoung S. Kwon , Seoung-Joo Lee , Young Ho Kim , Ho-Sik Oh , Joong Won Lee
- 申请人： Eutilex Co., Ltd.
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61P35/00 ; A61K39/395 ; A61K45/06 ; A61P37/04
摘要：
Provided are anti-human 4-1BB antibodies and fragments thereof with one or more structural features that are not found in a reference anti-human 4-1BB antibody, where said features may improve certain characteristics of the antibody relative to a reference antibody. Various in vitro and in vivo methods and reagents related to anti-human 4-1BB antibodies described herein are also provided. Methods include, for example, inducing T-cell proliferation, inducing T cell secretion of IFNγ, as well as detection, prevention, and/or therapeutic treatment of cancer using an anti-human 4-1BB antibody or fragment thereof.
公开/授权文献:
- US10919972B2 Anti-human 4-1BB antibodies and uses thereof 公开/授权日：2021-02-16
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |