基本信息:
- 专利标题： TOXIC RNAi ACTIVE SEED SEQUENCES FOR KILLING CANCER CELLS
- 申请号：US15900392 申请日：2018-02-20
- 公开(公告)号：US20180320187A1 公开(公告)日：2018-11-08
- 发明人： Marcus E. Peter , William E. Putzbach , Andrea E. Murmann , Monal Patel , Quan Gao
- 申请人： Northwestern University
- 申请人地址： US IL Evanston
- 专利权人： Northwestern University
- 当前专利权人： Northwestern University
- 当前专利权人地址： US IL Evanston
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K47/69 ; A61K47/64 ; A61K31/713 ; A61P35/00
摘要：
Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.”
公开/授权文献:
- US11613754B2 Toxic RNAi active seed sequences for killing cancer cells 公开/授权日：2023-03-28