基本信息:
- 专利标题： Microfluidic Model of the Blood Brain Barrier
- 申请号：US15955383 申请日：2018-04-17
- 公开(公告)号：US20180298332A1 公开(公告)日：2018-10-18
- 发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
- 申请人： EMULATE, Inc. , Cedars-Sinai Medical Center
- 主分类号： C12N5/0793
- IPC分类号： C12N5/0793 ; C12N5/071 ; C12M3/06 ; C12M1/12 ; C12M1/42
摘要：
The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.