基本信息:
- 专利标题： DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE
- 申请号：US15924089 申请日：2018-03-16
- 公开(公告)号：US20180215749A1 公开(公告)日：2018-08-02
- 发明人： Mitchell A. deLong , Jill M. Sturdivant , Susan M. Royalty
- 申请人： Aerie Pharmaceuticals, Inc.
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D401/12 ; C07C237/42 ; C07D217/02 ; C07D333/38 ; C07D409/12 ; C07D413/12
摘要：
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
公开/授权文献:
- US10174017B2 Dual mechanism inhibitors for the treatment of disease 公开/授权日：2019-01-08
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D417/00 | 杂环化合物，含两个或更多个杂环、至少有1个环有氮原子和硫原子作为仅有的杂环原子，C07D415/00组不包含的 |
| --------C07D417/02 | .含有两个杂环 |
| ----------C07D417/12 | ..被含有杂原子的链作为键链连接的 |