发明申请
US20180201652A1 CATIONIC PEPTIDOPOLYSACCHARIDES WITH EXCELLENT BROAD- SPECTRUM ANTIMICROBIAL ACTIVITIES AND HIGH SELECTIVITY
审中-公开
基本信息:
- 专利标题： CATIONIC PEPTIDOPOLYSACCHARIDES WITH EXCELLENT BROAD- SPECTRUM ANTIMICROBIAL ACTIVITIES AND HIGH SELECTIVITY
- 申请号：US15841236 申请日：2017-12-13
- 公开(公告)号：US20180201652A1 公开(公告)日：2018-07-19
- 发明人： Bee Eng Mary Chan , Peng Li
- 申请人： NANYANG TECHNOLOGICAL UNIVERSITY
- 申请人地址： SG Singapore
- 专利权人： NANYANG TECHNOLOGICAL UNIVERSITY
- 当前专利权人： NANYANG TECHNOLOGICAL UNIVERSITY
- 当前专利权人地址： SG Singapore
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; C07K4/00 ; A01N43/16 ; C08L5/08 ; C07H15/12 ; C07H13/04 ; C08L89/00 ; C08H1/00 ; C07H15/18 ; C08B37/08
摘要：
The disclosure provides cationic peptidopolysaccharides of Formula I: which has a bacterial peptidoglycan-mimetic structure, and shows outstanding broad spectrum activities against clinically significant bacteria and fungi. The structural affinity of these compounds with microbial cell wall constituents promotes its passage to the cytoplasmic membrane resulting in excellent antimicrobial activity and record high selectivity. The disclosure also describes methods of making and using cationic peptidopolysaccharides of Formula I.