基本信息:
- 专利标题： ROR GAMMA (RORY) MODULATORS
- 申请号：US15579111 申请日：2016-06-03
- 公开(公告)号：US20180170877A1 公开(公告)日：2018-06-21
- 发明人： Joseph Maria Gerardus Barbara CALS , Vera DE KIMPE , Sander Bernardus NABUURS
- 申请人： LEAD PHARMA HOLDING B.V. , SANOFI
- 申请人地址： NL Nijmegen FR Paris
- 专利权人： LEAD PHARMA HOLDING B.V.,SANOFI
- 当前专利权人： LEAD PHARMA HOLDING B.V.,SANOFI
- 当前专利权人地址： NL Nijmegen FR Paris
- 优先权： EP15170762.7 20150605
- 国际申请： PCT/EP2016/062688 WO 20160603
- 主分类号： C07D213/75
- IPC分类号： C07D213/75 ; C07D213/82 ; C07C317/50
摘要：
Compounds according to Formula I: or a pharmaceutically acceptable salt wherein: A1 is NR1 or CR1, with R1 herein; the cyclopropyl moiety with one or more methyl and one or more F; A2-A5 are N or CR2-CR5, with no more than two of the four positions A in A2-A5 can be simultaneously N; R2-R5 are described; R6 and R7 are independently H, F, methyl, ethyl, hydroxyl or methoxy or R6 and R7 together is carbonyl, all alkyl groups, if substituted with one or more F; R8 is H or C(1-6)alkyl; A9-A12 are N or CR9-CR12, with no more than two of the four positions A in A9-A12 can be simultaneously N; R9-R12 herein; R13 and R14 herein; or R13 and R14 fused forming a ring having 5 to 7 atoms by joining R13 being C(1-6)alkyl or C(2-6)alkenyl. The RORγ compounds can treat RORγ mediated diseases.
公开/授权文献:
- US10315996B2 ROR gamma (RORγ) modulators 公开/授权日：2019-06-11
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D213/00 | 杂环化合物，含六元环、不与其他环稠合、有1个氮原子作为仅有的杂环原子、环原子间或环原子与非环原子间有3个或更多个双键 |
| --------C07D213/02 | .环原子间或环原子与非环原子间有3个双键 |
| ----------C07D213/04 | ..在环氮原子与非环原子间没有键或只有氢或碳原子直接连在环氮原子上 |
| ------------C07D213/06 | ...除了环氮原子外，只含氢和碳原子 |
| --------------C07D213/62 | ....氧或硫原子 |
| ----------------C07D213/75 | .....胺基或亚胺基，被羧酸或碳酸酰化，或被它们的硫或氮的类似物所酰化，例如氨基甲酸酯 |