发明申请
US20180155718A1 RNA DUPLEXES WITH SINGLE STRANDED PHOSPHOROTHIOATE NUCLEOTIDE REGIONS FOR ADDITIONAL FUNCTIONALITY
审中-公开
基本信息:
- 专利标题： RNA DUPLEXES WITH SINGLE STRANDED PHOSPHOROTHIOATE NUCLEOTIDE REGIONS FOR ADDITIONAL FUNCTIONALITY
- 申请号：US15638586 申请日：2017-06-30
- 公开(公告)号：US20180155718A1 公开(公告)日：2018-06-07
- 发明人： Tod M. Woolf , Joanne Kamens , William Salomon , Anastasia Khvorova
- 申请人： RXi Pharmaceuticals Corporation
- 申请人地址： US MA Marlborough
- 专利权人： RXi Pharmaceuticals Corporation
- 当前专利权人： RXi Pharmaceuticals Corporation
- 当前专利权人地址： US MA Marlborough
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
The present invention relates to RNAi constructs and their use in gene silencing. RNAi constructs associated with the invention contain a double stranded region connected to a single stranded region of phosphorothioate modified nucleotides.