基本信息:
- 专利标题： SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE
- 申请号：US15819732 申请日：2017-11-21
- 公开(公告)号：US20180118699A1 公开(公告)日：2018-05-03
- 发明人： Steven MARX , Elaine WAN , Donald LANDRY , Sergey SAKHAROV , Guoxia LIU , Shi-Xian DENG , Xiaoming XU
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 主分类号： C07D277/84
- IPC分类号： C07D277/84 ; A61K31/428 ; A61K45/06 ; A61P9/04 ; A61P9/12 ; A61P3/10
摘要：
The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided. Methods and kits for treating or ameliorating the effects of heart failure syndrome, high blood pressure and diabetes also are provided. Methods, kits and compositions which include compounds of the present invention also are provided.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D277/00 | 杂环化合物，含有1,3-噻唑或氢化1,3-噻唑环 |
| --------C07D277/02 | .不和其他环稠合 |
| ----------C07D277/84 | ..萘并噻唑 |