Systems for managing pressure in a fluid reservoir chamber of a fluid infusion device are provided. For example, a fluid infusion device comprises a housing having a reservoir chamber that receives a fluid reservoir and a pump chamber. The fluid infusion device also includes a drive system contained within the pump chamber, and the drive system includes a slide that is movable relative to the fluid reservoir. The slide includes a proximal slide end that cooperates with a portion of the fluid reservoir to dispense fluid, and the proximal slide end has a projection. The fluid infusion device includes a pressure management system defined in the projection of the slide. The pressure management system includes at least one bore defined through the projection. The at least one bore is spaced a distance apart from a perimeter of the projection to vent air from the reservoir chamber into the pump chamber.